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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HCN2 All Species: 7.88
Human Site: S146 Identified Species: 24.76
UniProt: Q9UL51 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UL51 NP_001185.3 889 96950 S146 G P A E E A G S E E A G P A G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001115891 777 86237 A85 E R V K S A G A W I I H P Y S
Dog Lupus familis XP_855233 837 92350 R95 T C G V R V P R P R S A S S Y
Cat Felis silvestris
Mouse Mus musculus O88703 863 94703 S119 S A A E E A G S E E A G P A G
Rat Rattus norvegicus Q9JKA9 863 94902 S119 A A A E E A G S E E A G P A G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_425050 1188 129247 G131 D K S P S G S G E T Q G L P V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_685414 901 101015 Q93 F S K S E D G Q I T A E D G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24278 665 75805
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 57.5 79.1 N.A. 91.7 91.4 N.A. N.A. 49.6 N.A. 70.8 N.A. 20.5 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 66.8 82 N.A. 92.8 92.3 N.A. N.A. 56.8 N.A. 76.8 N.A. 37.9 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 20 0 N.A. 86.6 86.6 N.A. N.A. 13.3 N.A. 20 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 33.3 13.3 N.A. 86.6 86.6 N.A. N.A. 20 N.A. 20 N.A. 0 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 25 38 0 0 50 0 13 0 0 50 13 0 38 0 % A
% Cys: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 13 0 0 0 0 13 0 0 0 0 0 0 13 0 0 % D
% Glu: 13 0 0 38 50 0 0 0 50 38 0 13 0 0 13 % E
% Phe: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 13 0 13 0 0 13 63 13 0 0 0 50 0 13 38 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 13 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 13 13 13 0 0 0 0 % I
% Lys: 0 13 13 13 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 13 0 13 0 0 13 0 13 0 0 0 50 13 0 % P
% Gln: 0 0 0 0 0 0 0 13 0 0 13 0 0 0 0 % Q
% Arg: 0 13 0 0 13 0 0 13 0 13 0 0 0 0 0 % R
% Ser: 13 13 13 13 25 0 13 38 0 0 13 0 13 13 13 % S
% Thr: 13 0 0 0 0 0 0 0 0 25 0 0 0 0 0 % T
% Val: 0 0 13 13 0 13 0 0 0 0 0 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _